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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-Tianeptinostat
Tianeptinostat

Chemical Structure : Tianeptinostat

CAS No.: 2234283-90-8

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Tianeptinostat

货号: PC-35281Not For Human Use, Lab Use Only.

Tianeptinostat is a potent class I HDAC inhibitor with IC50 of 28, 33 and 51 nM for HDAC1, 2 and 3, respectively, also inhibits HDAC6 (IC50=1.6 nM) but not HDAC5 (IC50>80 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Tianeptinostat is a potent class I HDAC inhibitor with IC50 of 28, 33 and 51 nM for HDAC1, 2 and 3, respectively, also inhibits HDAC6 (IC50=1.6 nM) but not HDAC5 (IC50>80 uM).
    Tianeptinostat has EC50 of 1.72 and 7.66 uM in H3K9ac and H4K12ac assays, respectively.

    物理化学性质&存储条件

    分子量 437.939
    分子式 C20H24ClN3O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)-N-hydroxyhexanamide

    参考文献

    1. Zhao WN, et al. ACS Chem Neurosci. 2018 Jun 22. doi: 10.1021/acschemneuro.8b00116.

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