Thymidine Phosphorylase inhibitor 8g |CAS 2270189-39-2 Probechem Biochemicals

Chemical Structure : Thymidine Phosphorylase inhibitor 8g

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Thymidine Phosphorylase inhibitor 8g (hTP inhibitor 8g)

货号: PC-35965Not For Human Use, Lab Use Only.

Thymidine Phosphorylase inhibitor 8g (hTP inhibitor 8g) is a novel potent, selective inhibitor of human thymidine phosphorylase (hTP) with IC50 of 0.12 uM.

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生物&药学活性

Thymidine Phosphorylase inhibitor 8g (hTP inhibitor 8g) is a novel potent, selective inhibitor of human thymidine phosphorylase (hTP) with IC50 of 0.12 uM.
hTP inhibitor 8g induces DNA damage measured with the alkaline comet assay in HepG2 cells.
hTP inhibitor 8g (50 mg/kg/day) for two weeks (5 days/week) significantly reduced tumor growth using an in vivo glioblastoma model.

物理化学性质&存储条件

分子量	341.105
分子式	C8H12IN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(((1,3-dihydroxypropan-2-yl)amino)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione

参考文献

1. Sperotto N, et al. J Med Chem. 2019 Jan 7. doi: 10.1021/acs.jmedchem.8b01305.

Thymidine Phosphorylase inhibitor 8g (hTP inhibitor 8g)

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Thymidine Phosphorylase inhibitor 8g (hTP inhibitor 8g)

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物理化学性质&存储条件

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