Chemical Structure : Thr-Asp-F-amidine
货号: PC-62360Not For Human Use, Lab Use Only.
Thr-Asp-F-amidine (TDFA) is a highly potent, selective PAD4 (protein arginine deiminase 4) inhibitor with IC50 of 2.3 uM, displays ≥15-fold selectivity for PAD4 versus PAD1 and ≥50-fold versus PADs 2 and 3.
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Thr-Asp-F-amidine (TDFA) is a highly potent, selective PAD4 (protein arginine deiminase 4) inhibitor with IC50 of 2.3 uM, displays ≥15-fold selectivity for PAD4 versus PAD1 and ≥50-fold versus PADs 2 and 3.
TDFA is active in cells and can be used to inhibit PAD4 activity in cellulo.
分子量 | 448.452 | |
分子式 | C17H29FN6O7 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
1. Jones JE, et al. ACS Chem Biol. 2012 Jan 20;7(1):160-5.
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