Thiazovivin

Chemical Structure : Thiazovivin

CAS No.: 1226056-71-8

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货号: PC-43437Not For Human Use, Lab Use Only.

Thiazovivin is a small molecule inhibitor of ROCK, dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts.

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生物&药学活性

Thiazovivin is a small molecule inhibitor of ROCK, dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts.
Thiazovivin dramatically improves the survival of hESCs upon trypsinization.
Addition of Thiazovivin to cocktail of SB431542 and PD0325901 also vastly improves the survival of iPSCs after splitting by trypsinization.
Thiazovivin induces porcine embryonic fibroblasts into adipocytes.

物理化学性质&存储条件

分子量	311.36
分子式	C15H13N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	4-Thiazolecarboxamide, N-(phenylmethyl)-2-(4-pyrimidinylamino)-

参考文献

1. Lin T, et al. Nat Methods. 2009 Nov;6(11):805-8.

2. Zhu J, et al. Cell Reprogram. 2012 Apr;14(2):99-105.

3. Wang F, et al. Gastroenterology. 2013 Aug;145(2):383-95.e1-21.

4. Mohseni R, et al. Cell Biol Int. 2015 May;39(5):515-8.

Thiazovivin

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