Thiamet G | O-GlcNAcase inhibitor | Probechem Biochemicals

Chemical Structure : Thiamet G

CAS No.: 1009816-48-1

加入收藏

Thiamet G (Thiamet-G)

货号: PC-43111Not For Human Use, Lab Use Only.

Thiamet-G (Thiamet G) is a potent, selective O-GlcNAcase (OGA) inhibitor with Ki of 21 nM for human O-GlcNAcase, blocks phosphorylation of tau both in vitro and in vivo.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Thiamet-G (Thiamet G) is a potent, selective O-GlcNAcase (OGA) inhibitor with Ki of 21 nM for human O-GlcNAcase, blocks phosphorylation of tau both in vitro and in vivo.
Thiamet-G decreases phosphorylation of tau in PC-12 cells at pathologically relevant sites including Thr231 and Ser396.
Thiamet-G also efficiently reduces phosphorylation of tau at Thr231, Ser396 and Ser422 in both rat cortex and hippocampus, which reveals the rapid and dynamic relationship between O-GlcNAc and phosphorylation of tau in vivo.
Thiamet-G stimulates chondrogenic differentiation both in vitro and in vivo.

物理化学性质&存储条件

分子量	248.2993
分子式	C9H16N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 45 mg/mL
Chemical Name/SMILES	5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)-

参考文献

1. Yuzwa SA, et al. Nat Chem Biol. 2008 Aug;4(8):483-90.

2. Goldberg H, et al. Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E713-26.

3. Yuzwa SA, et al. Nat Chem Biol. 2012 Feb 26;8(4):393-9.

4. Andrés-Bergós J, et al. J Biol Chem. 2012 Sep 28;287(40):33615-28.

Thiamet G (Thiamet-G)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Thiamet G (Thiamet-G)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.