Them1 inhibitor U1

Chemical Structure : Them1 inhibitor U1

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货号: PC-21866Not For Human Use, Lab Use Only.

Them1 inhibitor U1 is a selective, allosteric small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 8.64 uM, selectively bind the Them1 START domain with Kd of 5.97 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Them1 inhibitor U1 is a selective, allosteric small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 8.64 uM, selectively bind the Them1 START domain with Kd of 5.97 uM.
Them1 inhibitor U1 (10 uM) increases fatty acid oxidation rates in cultured primary brown adipocytes.
Them1 inhibitor U1 reverses Them1-mediated suppression of oxygen consumption rates and increases in glucose production in cell culture.

物理化学性质&存储条件

分子量	383.51
分子式	C21H25N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 4-((2-methyl-1H-indol-3-yl)(thiophen-2-yl)methyl)piperazine-1-carboxylate

参考文献

1. Krumm CS, et al. Mol Metab. 2023 Dec;78:101832.