Them1 inhibitor Compound U1

Chemical Structure : Them1 inhibitor Compound U1

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货号: PC-25885Not For Human Use, Lab Use Only.

Them1 inhibitor Compound U1 is a small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 8.64 uM, selectively inhibits Them1 by binding the START domain (Kd=5.97 uM).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Them1 inhibitor Compound U1 is a small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 8.64 uM, selectively inhibits Them1 by binding the START domain (Kd=5.97 uM).
U1 binds to and destabilizes the Them1 START domain.
U1 (10 uM) increase fatty acid oxidation rates in cultured primary brown adipocytes.
U1 (33 uM) increase fatty acid oxidation rates and suppress glucose production in cultured primary hepatocytes.

物理化学性质&存储条件

分子量	383.51
分子式	C21H25N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 4-((2-methyl-1H-indol-3-yl)(thiophen-2-yl)methyl)piperazine-1-carboxylate

参考文献

1. Krumm CS, et al. Mol Metab. 2023 Dec;78:101832.