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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Calcium Channel -Thapsigargin
Thapsigargin

Chemical Structure : Thapsigargin

CAS No.: 67526-95-8

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Thapsigargin (G-202, G202)

货号: PC-60883Not For Human Use, Lab Use Only.

Thapsigargin (G202) is a potent, selective, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causes ER stress and induces autophagy in mammalian cells.

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5 mg ￥2280 In stock
10 mg ￥3680 In stock
25 mg ￥5680 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Thapsigargin (G202) is a potent, selective, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causes ER stress and induces autophagy in mammalian cells.
Thapsigargin inhibits the Ca2+ ATPase of rat liver ER about 100% at 170 nM, but no inhibition for skeletal muscle SR.
Thapsigargin increases the concentration of cytosolic free Ca2+ in sensitive cells by an acute and highly specific arrest of the endoplasmic reticulum Ca2+ pump.
Thapsigargin also efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication.

物理化学性质&存储条件

分子量 650.76
分子式 C34H50O12
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6- (Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate

参考文献

1. Davidson GA, et al. J Biol Chem. 1995 May 19;270(20):11731-4.

2. Thastrup O, et al. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2466-70.

3. Yu M, et al. J Biol Chem. 1998 Feb 6;273(6):3542-6.

4. Panagaki T, et al. Sci Rep. 2017 Nov 23;7(1):16158.

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