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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Thanatin TFA
Thanatin TFA

Chemical Structure : Thanatin TFA

CAS No.:

Thanatin TFA

货号: PC-28583Not For Human Use, Lab Use Only.

Thanatin TFA is a 21-residue inducible insect defense peptide within antimicrobial activity against fungi and some Gram-positive bacteria with MIC of 0.6-20 uM, disrupts bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase, inhibits LPS transport (Lpt) LptC-LptA interaction, disrupting the assembly of the Lpt protein machinery.

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10 mg ¥1980 In stock
25 mg ¥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Thanatin TFA is a 21-residue inducible insect defense peptide within antimicrobial activity against fungi and some Gram-positive bacteria with MIC of 0.6-20 uM, disrupts bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase, inhibits LPS transport (Lpt) LptC-LptA interaction, disrupting the assembly of the Lpt protein machinery.

物理化学性质&存储条件

分子量 2433.92 (free base)
分子式 C103H177N35O27S3.xC2HF3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Gly-Ser-Lys-Lys-Pro-Val-Pro-Ile-Ile-Tyr-Cys-Asn-Arg-Arg-Thr-Gly-Lys-Cys-Gln-Arg-Met (Disulfide bridge:Cys11-Cys18) TFA salt

参考文献

1. Fehlbaum P, et al. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-5.

2. Mandard N, et al. Eur J Biochem. 1998 Sep 1;256(2):404-10.

3. Javadmanesh A, et al. Sci Rep. 2021 May 25;11(1):10890.

4. Ma B, et al. Nat Commun. 2019 Aug 6;10(1):3517.

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