Ternatin-4 | eEF1A inhibitor | Probechem Biochemicals

Chemical Structure : Ternatin-4

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Ternatin-4 (Ternatin 4)

货号: PC-22060Not For Human Use, Lab Use Only.

Ternatin-4 is a small molecule elongation factor-1alpha (eEF1A) inhibitor, triggers the ubiquitination and degradation of eEF1A on stalled ribosomes, targets the complex of eEF1A bound to aminoacyl-tRNAs (aa-tRNA).

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生物&药学活性

Ternatin-4 is a small molecule elongation factor-1alpha (eEF1A) inhibitor, triggers the ubiquitination and degradation of eEF1A on stalled ribosomes, targets the complex of eEF1A bound to aminoacyl-tRNAs (aa-tRNA).
Ternatin-4 stalls elongation by preventing aa-tRNA release from eEF1A on the ribosome.
Ternatin-4 promotes eEF1A degradation in a manner that requires translating ribosomes.
Ternatin-4 promotes RNF14 and RNF25-dependent ubiquitination of eEF1A and ribosomal proteins.

物理化学性质&存储条件

分子量	776.03
分子式	C40H69N7O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(9S,12S,15S,18S,24aR)-6-((S)-sec-butyl)-3-((R)-1-hydroxy-2-methylpropyl)-12-isobutyl-8,9,11,17,18-pentamethyl-15-((R)-2-methylbut-3-en-1-yl)hexadecahydropyrido[1,2-a][1,4,7,10,13,16,19]heptaazacyclohenicosine-1,4,7,10,13,16,19(21H)-heptaone

参考文献

1. Oltion K, et al. Cell. 2023 Jan 19;186(2):346-362.e17.

2. Juette MF, et al. Elife. 2022 Oct 20;11:e81608.

Ternatin-4 (Ternatin 4)

生物&药学活性

物理化学性质&存储条件

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Ternatin-4 (Ternatin 4)

生物&药学活性

物理化学性质&存储条件

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