Tenovin-D3 |Cas:1258283-70-3 Probechem Biochemicals

Chemical Structure : Tenovin-D3

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Tenovin-D3 (Tenovin D3)

货号: PC-70105Not For Human Use, Lab Use Only.

Tenovin-D3 is a selective, small-molecule inhibitor of sirtuin SIRT2 with IC50 of 21.8 uM.

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生物&药学活性

Tenovin-D3 is a selective, small-molecule inhibitor of sirtuin SIRT2 with IC50 of 21.8 uM.
Tenovin-D3 shows much weaker actvity for SIRT1 (IC50>90 uM), SIRT3 and HDAC8.
Tenovin-D3 promotes expression of the cell-cycle regulator and p53 target p21(WAF1/CIP1) (CDKN1A) in a p53-independent manner, fails to increase p53 levels or transcription factor activity.

物理化学性质&存储条件

分子量	533.893
分子式	C22H27Cl3N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-dichloro-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)-4-methoxybenzamide hydrochloride

参考文献

1. McCarthy AR, et al. Mol Cancer Ther. 2013 Apr;12(4):352-60.

2. Liu R, et al. Sci Rep. 2015 Feb 12;5:8415.

Tenovin-D3 (Tenovin D3)

生物&药学活性

物理化学性质&存储条件

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Tenovin-D3 (Tenovin D3)

生物&药学活性

物理化学性质&存储条件

参考文献

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