Temsavir (BMS-626529)

Chemical Structure : Temsavir

CAS No.: 701213-36-7

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货号: PC-38563Not For Human Use, Lab Use Only.

Temsavir (BMS-626529) is a highly potent, small molecule HIV-1 attachment inhibitor with IC50 values of 2.26 nM, 0.34 nM and 1.3 nM for HIV-1 subtype A, B, and C envelope, repectively.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg	￥5880	In stock
250 mg		Get quote

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生物&药学活性

Temsavir (BMS-626529) is a highly potent, small molecule HIV-1 attachment inhibitor with IC50 values of 2.26 nM, 0.34 nM and 1.3 nM for HIV-1 subtype A, B, and C envelope, repectively.
Temsavir (BMS-626529) binds to non-ligand bound HIV-1 gp120 to inhibit HIV-1 interaction with host CD4+ T cells and subsequent HIV-1 binding and cell entry.
Temsavir (BMS-626529) inhibits infectivity of laboratory strains and clinical isolates of HIV-1 with EC50s of 0.4-2,000 nM, with no significant cytotoxic effect.
Temsavir (BMS-626529) is the active form of Fostemsavir.

物理化学性质&存储条件

分子量	473.5
分子式	C24H23N7O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-benzoylpiperazin-1-yl)-2-[4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione

参考文献

1. Meanwell NA, et al. J Med Chem. 2018 Jan 11;61(1):62-80.

2. Wang T, et al. J Med Chem. 2018 Jul 26;61(14):6308-6327.

3. Lai YT, et al. Nat Commun. 2019 Jan 3;10(1):47.