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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Telomerase-Teloxantron
Teloxantron

Chemical Structure : Teloxantron

CAS No.: 2016813-83-3

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Teloxantron (Telomerase inhibitor TXT4)

货号: PC-49795Not For Human Use, Lab Use Only.

Teloxantron (Telomerase inhibitor TXT4) is a potent small molecule inhibitor of telomerase activity with IC50 of 9.61 uM, 7-fold lower than BIBR1532 (Cat# PC-45170), inhibits the processivity of telomerase with preferential DNA damage on telomeres.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Teloxantron (Telomerase inhibitor TXT4) is a potent small molecule inhibitor of telomerase activity with IC50 of 9.61 uM, 7-fold lower than BIBR1532 (Cat# PC-45170), inhibits the processivity of telomerase with preferential DNA damage on telomeres.
TXT4 induces remarkable and time-dependent induction of DNA damage in TERT-positive (A549 and H460), but not in TERT-negative NHBE normal human bronchial epithelial and ALT-positive U2OS osteosarcoma cell lines.
TXT4 caused an increase in the phosphorylation of ATM and ATR, two main DDR signaling kinases, in both A549 and H460 cells, stimulats apoptotic cell death via the intrinsic and extrinsic pathway in lung cancer cells.

物理化学性质&存储条件

分子量 355.47
分子式 C19H17NO2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9,10-dioxo-9,10-dihydroanthracen-1-yl diethylcarbamodithioate

参考文献

1. Natalia Maciejewska, et al. Cell Death Dis. 2022 Nov 28;13(11):1005.

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