Tegoprazan (CJ 12420) |CAS:942195-55-3 Probechem Biochemicals

Chemical Structure : Tegoprazan

CAS No.: 942195-55-3

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Tegoprazan (CJ 12420, RQ-00000004, RQ-4)

货号: PC-60811Not For Human Use, Lab Use Only.

Tegoprazan (CJ 12420, RQ-00000004, RQ-4) is a novel potent, highly selective, competitive and orally active inhibitor of gastric H+/K+-ATPase with IC50 of ranging 0.29-0.52 uM porcine, canine and human H+/K+-ATPases in vitro.

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5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

Tegoprazan (CJ 12420, RQ-00000004, RQ-4) is a novel potent, highly selective, competitive and orally active inhibitor of gastric H+/K+-ATPase with IC50 of ranging 0.29-0.52 uM porcine, canine and human H+/K+-ATPases in vitro.
Tegoprazan displays no activity against canine kidney Na+/K+-ATPase (IC50>100 uM).
Tegoprazan potently inhibits histamine-induced gastric acid secretion in dogs and a complete inhibition at 1.0 mg/kg starting from 1 hr after administration, reverses the pentagastrin-induced acidified gastric pH to the neutral range at 1-3 mg/kg, immediately evoks a gastric phase III contraction of migrating motor complex (MMC) in pentagastrin-treated dogs.

物理化学性质&存储条件

分子量	387.387
分子式	C20H19F2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-((5,7-difluorochroman-4-yl)oxy)-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide

参考文献

1. Takahashi N, et al. J Pharmacol Exp Ther. 2017 Nov 27. pii: jpet.117.244202.

Tegoprazan (CJ 12420, RQ-00000004, RQ-4)

生物&药学活性

物理化学性质&存储条件

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Tegoprazan (CJ 12420, RQ-00000004, RQ-4)

生物&药学活性

物理化学性质&存储条件

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