Teglicar (ST-1326) | CPT1 inhibitor | Probechem Biochemicals

Chemical Structure : Teglicar

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Teglicar (ST-1326, ST1326)

货号: PC-61316Not For Human Use, Lab Use Only.

Teglicar (ST-1326) is a potent, selective and reversible inhibitor of liver carnitine palmitoyl-transferase 1 (L-CPT1) with IC50 of 0.68 uM, Ki of 0.36 uM.

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生物&药学活性

Teglicar (ST-1326) is a potent, selective and reversible inhibitor of liver carnitine palmitoyl-transferase 1 (L-CPT1) with IC50 of 0.68 uM, Ki of 0.36 uM.
Teglicar displays an extraordinarily high selectivity (39-fold) toward the liver isoform over the heart isoform (muscle-CPT1;M-CPT1).
Teglicar reduces gluconeogenesis and improves glucose homeostasis, shows antiketotic and antidiabetic activity in diabetic db/db mice.
Teglicar also inhibits fatty acid oxidation associated with cell growth arrest, mitochondrial damage, and apoptosis induction in leukemia cell lines.
Teglicar is orally active.

物理化学性质&存储条件

分子量	399.62
分子式	C22H45N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-Trimethylammonio-3-[(tetradecylcarbamoyl)amino]butyrate

参考文献

1. Ricciardi MR, et al. Blood. 2015 Oct 15;126(16):1925-9.

2. Giannessi F, et al. J Med Chem. 2003 Jan 16;46(2):303-9.

3. Conti R, et al. Diabetes. 2011 Feb;60(2):644-51.

Teglicar (ST-1326, ST1326)

生物&药学活性

物理化学性质&存储条件

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Teglicar (ST-1326, ST1326)

生物&药学活性

物理化学性质&存储条件

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