Tedizolid (TR-700, DA-7157)

Chemical Structure : Tedizolid

CAS No.: 856866-72-3

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货号: PC-20075Not For Human Use, Lab Use Only.

Tedizolid (TR-700, DA-7157) is an oxazolidinone antibiotic with activity against mycobacterium tuberculosis and nocardia brasiliensis with MIC50 of 0.25 ug/mL.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg	￥3980	In stock
250 mg		Get quote

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生物&药学活性

Tedizolid (TR-700, DA-7157) is an oxazolidinone antibiotic with activity against mycobacterium tuberculosis and nocardia brasiliensis with MIC50 of 0.25 ug/mL.
Tedizolid shows MIC50 value 0.25 ug/mL against methicillin-resistant Staphylococcus aureus (MRSA) isolates.
Tedizolid demonstrated greater in vitro potency than linezolid against staphylococci, including linezolid-resistant and vancomycin-nonsusceptible strains, and was 32-fold more active than linezolid against the seven cfr-positive MRSA strains tested.
Tedizolid demonstrated MIC(90) of ≤0.5 μg/ml against clinical isolates of major aerobic and anaerobic bacteria.

物理化学性质&存储条件

分子量	370.34
分子式	C17H15FN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one

参考文献

1. Locke JB, et al. Antimicrob Agents Chemother. 2009 Dec;53(12):5265-74.

2. Vera-Cabrera L, et al. Antimicrob Agents Chemother. 2006 Sep;50(9):3170-2.

3. Yum JH, et al. Antimicrob Agents Chemother. 2010 Dec;54(12):5381-6.