Teclistamab | Anti-BCMA/CD3 | Probechem Biochemicals

Chemical Structure : Teclistamab

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Teclistamab (JNJ-64007957)

货号: PC-38852Not For Human Use, Lab Use Only.

Teclistamab (JNJ-64007957) is a BCMAxCD3 bispecific antibody, recruits and activates T cells to kill BCMA-expressing MM cells.

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生物&药学活性

Teclistamab (JNJ-64007957) is a BCMAxCD3 bispecific antibody, recruits and activates T cells to kill BCMA-expressing MM cells.
Teclistamab induced cytotoxicity of BCMA+ MM cell lines in vitro (H929 cells, EC50=0.15 nM; MM.1R cells, EC50=0.06 nM; RPMI 8226 cells, EC50=0.45 nM).
Teclistamab also depleted BCMA+ cells in bone marrow samples from MM patients in an ex vivo assay with an average EC50 value of 1.7 nM.
Teclistamab demonstrated excellent antitumor activity BCMA+ MM murine xenograft models inoculated with human T cells (tumor inhibition with H929 model and tumor regression with the RPMI 8226 model).

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Moreau P, et al. N Engl J Med. 2022 Jun 5. doi: 10.1056/NEJMoa2203478.

2. Pillarisetti K, et al. Blood Adv. 2020 Sep 22;4(18):4538-4549.

3. Usmani SZ, et al. Lancet. 2021 Aug 21;398(10301):665-674.

Teclistamab (JNJ-64007957)

生物&药学活性

物理化学性质&存储条件

参考文献

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Teclistamab (JNJ-64007957)

生物&药学活性

物理化学性质&存储条件

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