Chemical Structure : Teclistamab
货号: PC-38852Not For Human Use, Lab Use Only.
Teclistamab (JNJ-64007957) is a BCMAxCD3 bispecific antibody, recruits and activates T cells to kill BCMA-expressing MM cells.
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Teclistamab (JNJ-64007957) is a BCMAxCD3 bispecific antibody, recruits and activates T cells to kill BCMA-expressing MM cells.
Teclistamab induced cytotoxicity of BCMA+ MM cell lines in vitro (H929 cells, EC50=0.15 nM; MM.1R cells, EC50=0.06 nM; RPMI 8226 cells, EC50=0.45 nM).
Teclistamab also depleted BCMA+ cells in bone marrow samples from MM patients in an ex vivo assay with an average EC50 value of 1.7 nM.
Teclistamab demonstrated excellent antitumor activity BCMA+ MM murine xenograft models inoculated with human T cells (tumor inhibition with H929 model and tumor regression with the RPMI 8226 model).
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外观性状 | Solid | |
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Solubility |
10 mM in DMSO |
1. Moreau P, et al. N Engl J Med. 2022 Jun 5. doi: 10.1056/NEJMoa2203478.
2. Pillarisetti K, et al. Blood Adv. 2020 Sep 22;4(18):4538-4549.
3. Usmani SZ, et al. Lancet. 2021 Aug 21;398(10301):665-674.
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