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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Tec Kinase-Tec Kinase-IN-14
Tec Kinase-IN-14

Chemical Structure : Tec Kinase-IN-14

CAS No.: 852838-07-4

Tec Kinase-IN-14

货号: PC-60853Not For Human Use, Lab Use Only.

A selective small molecule toward Tec kinase-mediated tyrosine phosphorylation of FGF2 with IC50 of 7.0 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Tec Kinase-IN-14 is a selective small molecule toward Tec kinase-mediated tyrosine phosphorylation of FGF2 with IC50 of 7.0 uM.
    Tec Kinase-IN-14 inhibits Tec-FGF2 complex and blocks tyrosine phosphorylation of FGF2 in cells, also inhibit FGF2 secretion from cells.

    物理化学性质&存储条件

    分子量 418.247
    分子式 C18H16BrN3O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (7-bromo-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl 4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylate

    参考文献

    1. La Venuta G, et al. J Biol Chem. 2016 Aug 19;291(34):17787-803.

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