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首页-小分子抑制剂&激动剂-Others-Other Targets-Tazbentetol
Tazbentetol

Chemical Structure : Tazbentetol

CAS No.: 2274723-90-7

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Tazbentetol (SPG302, SPG-302)

货号: PC-27508Not For Human Use, Lab Use Only.

Tazbentetol (SPG302) is a pegylated benzothiazole derivative and synaptic regenerative small molecule, targets the cytoskeleton and induces the formation of new glutamatergic synapses.

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25 mg ￥2480 In stock
50 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Tazbentetol (SPG302) is a pegylated benzothiazole derivative and synaptic regenerative small molecule, targets the cytoskeleton and induces the formation of new glutamatergic synapses.
SPG302 administration ameliorates visual dysfunction, significantly improves retinal ganglion cell (RGC) function and conduction in db/db mice.
SPG302 administration preserves optic nerve myelination in db/db mice.
SPG302 administration preserved synapses in the retina of db/db mice.
SPG302 administration inhibits glial activation in the retina of db/db mice, inhibits apoptotic cell death in the retina.
SPG302 demonstrates therapeutic potential for inner retina protection and preservation of visual function in Diabetic retinal neuropathy (DRN).
SPG302 protects retinal ganglion cells and preserves visual function by preserving synaptic activity in a mouse model of glaucoma.

物理化学性质&存储条件

分子量 403.49
分子式 C21H25NO5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-(2-(2-(4-(Benzo[d]thiazol-2-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethan-1-ol

参考文献

1. Bastola T, et al. Exp Eye Res. 2025 Dec;261:110640.

2. Trujillo-Estrada L, et al. Neurotherapeutics. 2021 Oct;18(4):2468-2483.

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