Tariquidar methanesulfonate hydrate |CAS:625375-83-9 Probechem Biochemicals

Chemical Structure : Tariquidar methanesulfonate hydrate

CAS No.: 625375-83-9

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Tariquidar methanesulfonate hydrate (XR 9576;XR-9576;XR9576)

货号: PC-42649Not For Human Use, Lab Use Only.

A potent, specific P-gp inhibitor with Kd of 5.1 nM.

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50 mg	￥2520	In stock
100 mg	￥3960	In stock
250 mg		Get quote

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生物&药学活性

A potent, specific P-gp inhibitor with Kd of 5.1 nM; potentiates the cytotoxicity of several drugs including doxorubicin, paclitaxel, etoposide, and vincristine in a panel of human MDR cell lines at 25-80 nM; exhibits potent i.v. and p.o. activity without apparently enhancing the plasma pharmacokinetics of paclitaxel or the toxicity of coadministered drugs.

Breast Cancer

Phase 2 Discontinued

物理化学性质&存储条件

分子量	892.9887
分子式	C40H52N4O15S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 296 mg/mL; H2O: < 8.9 mg/mL
Chemical Name/SMILES	3-Quinolinecarboxamide, N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-, methanesulfonate, hydrate (1:2:3)

参考文献

1. Martin C, et al. Br J Pharmacol. 1999 Sep;128(2):403-11.

2. Mistry P, et al. Cancer Res. 2001 Jan 15;61(2):749-58.

3. Walker J, et al. Eur J Cancer. 2004 Mar;40(4):594-605.

Tariquidar methanesulfonate hydrate (XR 9576;XR-9576;XR9576)

生物&药学活性

物理化学性质&存储条件

参考文献

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Tariquidar methanesulfonate hydrate (XR 9576;XR-9576;XR9576)

生物&药学活性

物理化学性质&存储条件

参考文献

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