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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P-glycoprotein (P-gp)-Tariquidar
Tariquidar

Chemical Structure : Tariquidar

CAS No.: 206873-63-4

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Tariquidar (XR 9576;XR-9576;XR9576)

货号: PC-42648Not For Human Use, Lab Use Only.

Tariquidar (XR9576) is a potent, specific P-gp inhibitor with Kd of 5.1 nM.

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25 mg ￥2980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Tariquidar (XR9576) is a potent, specific P-gp inhibitor with Kd of 5.1 nM.
Tariquidar (XR9576) potentiates the cytotoxicity of several drugs including doxorubicin, paclitaxel, etoposide, and vincristine in a panel of human MDR cell lines at 25-80 nM.
Tariquidar (XR9576) exhibits potent i.v. and p.o. activity without apparently enhancing the plasma pharmacokinetics of paclitaxel or the toxicity of coadministered drugs.

物理化学性质&存储条件

分子量 646.7315
分子式 C38H38N4O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 100 mg/mL
Chemical Name/SMILES

3-Quinolinecarboxamide, N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-

参考文献

1. Martin C, et al. Br J Pharmacol. 1999 Sep;128(2):403-11.

2. Mistry P, et al. Cancer Res. 2001 Jan 15;61(2):749-58.

3. Walker J, et al. Eur J Cancer. 2004 Mar;40(4):594-605.

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