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首页-小分子抑制剂&激动剂-Epigenetics-MicroRNA-Targapremir-200c
Targapremir-200c

Chemical Structure : Targapremir-200c

CAS No.:

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Targapremir-200c (TGP-200c)

货号: PC-72544Not For Human Use, Lab Use Only.

Targapremir-200c (TGP-200c) is a structure-specific, small molecule inhibitor of miR-200c precursor (pre-miR-200c), binds to the Dicer site of pre-miR-200c with Kd of 50 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Targapremir-200c (TGP-200c) is a structure-specific, small molecule inhibitor of miR-200c precursor (pre-miR-200c), binds to the Dicer site of pre-miR-200c with Kd of 50 nM.
    TGP-200c inhibits Dicer processing of pre-miR-200c with IC50 320 nM, selectively engages pre-miR-200c in cells.
    TGP-200c potently inhibits miR-200c biogenesis selectively across the miRnome and modulates the downstream miR-200c pathway.
    TGP-200c selectively inhibits miR-200c over other miR-200 family members by recognizing the 1x1 UU internal loop unique to pre-miR-200c and an adjacent AU base pair simultaneously.
    TGP-200c selectively rescues a miR-200c-mediated phenotype in MIN6 cells, induces anti-apoptotic phenotype, modulates various T2D-related pathways, including insulin signaling and metabolism, represses pro-cell death factors and promotes β cell survival in specific ways.

    物理化学性质&存储条件

    分子量 1372.562
    分子式 C76H77N17O9
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(3-(1-(3-(N-(2-amino-2-oxoethyl)-2-(4-(2-hydroxy-5-(1H-phenanthro[9,10-d]imidazol-2-yl)phenoxy)-N-propylbutanamido)acetamido)propyl)-1H-1,2,3-triazol-4-yl)propoxy)-N1,N3,N5-tris(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)benzene-1,3,5-tricarboxamide

    参考文献

    1. Hafeez S Haniff, et al. Cell Chem Biol. 2022 Feb 17;29(2):300-311.e10.

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