Taprenepag isopropyl (PF-04217329) | EP2 receptor agonist

Chemical Structure : Taprenepag isopropyl

CAS No.: 1005549-94-9

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Taprenepag isopropyl (PF-04217329, PF04217329)

货号: PC-28387Not For Human Use, Lab Use Only.

Taprenepag isopropyl (PF-04217329) is the prodrug of Taprenepag (CP-544326), a potent and selective prostaglandin EP2 receptor agonist with IC50 of 10 nM and EC50 of 2.8 nM.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

Taprenepag isopropyl (PF-04217329) is the prodrug of Taprenepag (CP-544326), a potent and selective prostaglandin EP2 receptor agonist with IC50 of 10 nM and EC50 of 2.8 nM.
Taprenepag isopropyl (PF-04217329) shows increased corneal permeability and ocular bioavailability.
Taprenepag isopropyl (PF-04217329) causes sustained intraocular pressure (IOP) reduction, is a clinical candidate for treatment of glaucoma and ocular hypertension.

物理化学性质&存储条件

分子量	520.60
分子式	C27H28N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Isopropyl 2-(3-((N-(4-(1H-pyrazol-1-yl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetate

参考文献

1. Prasanna G, et al. Exp Eye Res. 2011 Sep;93(3):256-64.

2. Schachar RA, et al. Curr Eye Res. 2011 Sep;36(9):809-17.

3. Qu C, et al. Sci Adv. 2021 Apr 2;7(14):eabf1268.

Taprenepag isopropyl (PF-04217329, PF04217329)

生物&药学活性

物理化学性质&存储条件

参考文献

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Taprenepag isopropyl (PF-04217329, PF04217329)

生物&药学活性

物理化学性质&存储条件

参考文献

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