Tanzisertib (CC-930) | JNK inhibitor | Probechem Biochemicals

Chemical Structure : Tanzisertib

CAS No.: 899805-25-5

加入收藏

Tanzisertib (CC-930, CC930)

货号: PC-27738Not For Human Use, Lab Use Only.

Tanzisertib (CC-930) is a potent, selective, ATP-competitive and orally active c-Jun N-terminal kinase (JNK) inhibitor with IC50 of 61/5/5 nM for JNK1/2/3 respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Tanzisertib (CC-930) is a potent, selective, ATP-competitive and orally active c-Jun N-terminal kinase (JNK) inhibitor with IC50 of 61/5/5 nM for JNK1/2/3 respectively.
Tanzisertib (CC-930) is selective against MAP kinases ERK1 and p38α with IC50 of 0.48 and 3.4 μM respectively.
Tanzisertib (CC-930) has Ki values of 44 nM and 6.2 nM for JNK1 and JNK2 respectively.
Tanzisertib (CC-930) inhibits the formation of phospho-cJun in human PBMC stimulated by phorbol-12-myristate-13-acetate and phytohemeagglutinin (IC50=1 uM).
Tanzisertib (CC-930) shows remarkable selectivity in a panel of 240 kinases, EGFR being the only non-MAP kinase inhibited more than 50% at 3 μM (IC50 = 0.38 μM).
Tanzisertib (CC-930) inhibited the production of TNFα by 23% and 77% at 10 and 30 mg/kg oral dose respectively in acute rat LPS-induced TNFα production PK-PD model.

物理化学性质&存储条件

分子量	448.45
分子式	C21H23F3N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	trans-4-((9-((S)-tetrahydrofuran-3-yl)-8-((2,4,6-trifluorophenyl)amino)-9H-purin-2-yl)amino)cyclohexanol

参考文献

1. Nagy MA, et al. J Med Chem. 2021 Dec 23;64(24):18193-18208.

2. Plantevin Krenitsky V, et al. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1433-8.

3. Reich N, et al. Ann Rheum Dis. 2012 May;71(5):737-45.

Tanzisertib (CC-930, CC930)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Tanzisertib (CC-930, CC930)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.