Tamibarotene | RARα agonist | Probechem Biochemicals

Chemical Structure : Tamibarotene

CAS No.: 94497-51-5

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Tamibarotene (Am-80, SY-1425, SY1425)

货号: PC-21041Not For Human Use, Lab Use Only.

Tamibarotene (Am-80, SY-1425) is a potent and selective retinoic acid receptor α (RARα) agonist with high selectivity over RARγ, exhibits anti-angiogenic activity.

规格	价格	库存
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg	￥4980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Tamibarotene (Am-80, SY-1425) is a potent and selective retinoic acid receptor α (RARα) agonist with high selectivity over RARγ, exhibits anti-angiogenic activity.
Tamibarotene (Am-80, SY-1425) is a potent inhibitor of proliferation in the RARA-high AML cell lines, with EC50s that ranged from 0.14 nM-0.9 nM, with no effect on the RARA-low cell lines up to the highest concentration tested (2 μM).
Tamibarotene (Am-80, SY-1425) induces maturation in RARA-high AML, exerts transcriptional and chromatin alterations in RARA-high cell lines.

物理化学性质&存储条件

分子量	351.45
分子式	C22H25NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoic acid

参考文献

1. T Oikawa, et al. Eur J Pharmacol. 1993 Nov 2;249(1):113-6.

2. Nakazato T, et al. Cancer Sci. 2008 Nov;99(11):2286-94.

3. de Botton S, et al. Blood Adv. 2023 May 9;7(9):1858-1870.

4. McKeown MR, et al. Cancer Discov. 2017 Oct;7(10):1136-1153.

Tamibarotene (Am-80, SY-1425, SY1425)

生物&药学活性

物理化学性质&存储条件

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Tamibarotene (Am-80, SY-1425, SY1425)

生物&药学活性

物理化学性质&存储条件

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