Tamapin TFA

Chemical Structure : Tamapin TFA

CAS No.:

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货号: PC-21845Not For Human Use, Lab Use Only.

规格	价格	库存
2 mg	￥2480	In stock
5 mg	￥4280	In stock
10 mg	￥7280	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

Tamapin TFA salt is a venom peptide from the Indian red scorpion (Mesobuthus tamulus), potent and selective inhibitor of small conductance calcium-activated potassium channel 2 (SK2, KCNN2) with IC50 of 24 pM.
Tamapin displays remarkable selectivity for SK2 versus SK1 ( approximately 1750-fold) and SK3 ( approximately 70-fold) channels.
Tamapin mitigates physiological abnormalities in reporter-positive neurons in PAE mice.
Tamapin improves impaired motor skill learning in PAE mice.
Tamapin reverses learning deficits in a mouse model of fetal alcohol spectrum disorders.

物理化学性质&存储条件

分子量	3458.11 (free base)
分子式	C146H238N44O41S6.xC2HF3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ala-Phe-Cys-Asn-Leu-Arg-Arg-Cys-Glu-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Glu-Glu-Cys-Lys-Cys-Val-Pro-Tyr-NH2 (Disulfide bridge: Cys3-Cys21, Cys8-Cys26, Cys12-Cys28)

参考文献

1. Pedarzani P, et al. J Biol Chem. 2002 Nov 29;277(48):46101-9.

Tamapin TFA

生物&药学活性

物理化学性质&存储条件

参考文献

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Tamapin TFA

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