Taginostat

Chemical Structure : Taginostat

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货号: PC-27254Not For Human Use, Lab Use Only.

Taginostat is a potent and selective HDAC6 inhibitor with IC50 of 6.9 nM (hHDAC6), >45-fold selectivity over hHDAC1 and hHDAC8, activates the transcription factor STAT4 in CLL cells.

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生物&药学活性

Taginostat is a potent and selective HDAC6 inhibitor with IC50 of 6.9 nM (hHDAC6), >45-fold selectivity over hHDAC1 and hHDAC8, activates the transcription factor STAT4 in CLL cells.
Taginostat (1-5 uM, 24h) promotes apoptosis of CLL cells
Taginostat enhances p66Shc expression and alters mitochondrial homeostasis in CLL cells, shows significantly higher pro-apoptotic effects in CLL cells than both the HDAC6 inhibitors ACY-738 and tubastatin A, and the pan-HDAC inhibitor vorinostat (SAHA).
Taginostat enhances p66Shc expression in CLL cells by activating its transcription factor STAT4.
Taginostat promotes apoptosis and mitochondrial dysfunction in leukemic cells by enhancing p66Shc expression.
Taginostat synergizes with Ibrutinib to enhance p66Shc-dependent apoptosis of CLL cells.

物理化学性质&存储条件

分子量	547.70
分子式	C35H37N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((1-(4-((diethylamino)methyl)benzyl)-4-phenyl-1,2-dihydroquinolin-3-yl)oxy)methyl)-N-hydroxybenzamide

参考文献

1. Tatangelo V, et al. Apoptosis. 2026 Jul 4;31(7):186.

Taginostat

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物理化学性质&存储条件

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Taginostat

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