Tafbromin | TAF1(2) inhibitor | Probechem Biochemicals

Chemical Structure : Tafbromin

加入收藏

Tafbromin (TAF1(2) inhibitor cis-5)

货号: PC-22395Not For Human Use, Lab Use Only.

Tafbromin is a selective inhibitor of TAF1 bromodomain by binding to the second bromodomain (TAF1(2)) with KD of 260 nM, inhibits Hh pathway-dependent osteoblast differentiation.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Tafbromin is a selective inhibitor of TAF1 bromodomain by binding to the second bromodomain (TAF1(2)) with KD of 260 nM, inhibits Hh pathway-dependent osteoblast differentiation.
Tafbromin displays no significant binding affinity to BRD7, BRD9, BRPF1 andTRIM24 (KD>10 uM).
Tafbromin inhibits Purmorphamine-induced osteoblast differentiation by modulating canonical Hh signaling and this activity is cell-type dependent and does not involve SMO binding.
Tafbromin does not inhibit Wnt and BMP-induced reporter geneexpression.
Tafbromin reduced the expression of Gli1 and Ptch1 in C3H10T1/2 cells by approximately 75% at a concentration of 5 uM.
Tafbromin is a better selective TAF1 bromodomain 2 ligand compared with CeMMEC1, BAY-299 and GNE-371.

物理化学性质&存储条件

分子量	393.46
分子式	C23H24FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((5R,7R)-1-acetyl-7-(4-fluorophenyl)-2,3,5,6,7,8-hexahydro-1H-pyrrolo[3,2-g]quinolin-5-yl)pyrrolidin-2-one

参考文献

1. Patil S, et al. Angew Chem Int Ed Engl. 2024 May 27:e202404645.

Tafbromin (TAF1(2) inhibitor cis-5)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Tafbromin (TAF1(2) inhibitor cis-5)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.