Tafamidis

Chemical Structure : Tafamidis

CAS No.: 594839-88-0

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货号: PC-49858Not For Human Use, Lab Use Only.

Tafamidis is a potent and selective transthyretin (TTR) kinetic stabilizer with EC50 of 2.7-3.2 uM for WT-TTR and mutant tetramers V30M-TTR, V122I-TTR, inhibits amyloidogenesis.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg	￥4280	In stock
250 mg		Get quote

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生物&药学活性

Tafamidis is a potent and selective transthyretin (TTR) kinetic stabilizer with EC50 of 2.7-3.2 uM for WT-TTR and mutant tetramers V30M-TTR, V122I-TTR, inhibits amyloidogenesis.
Tafamidis (7.2 μM) also strongly stabilized TTR heterotetramers containing WT and mutant subunits in plasma samples from patients carrying V30M or V122I mutations in plasma from patients.
Tafamidis significantly reduced the disappearance of TTR tetramer by kinetic stabilization.

物理化学性质&存储条件

分子量	308.11
分子式	C14H7Cl2NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylic acid

参考文献

1. Bulawa CE, et al. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9629-34.

2. Lozeron P, et al. Eur J Neurol. 2013 Dec;20(12):1539-45.

Tafamidis

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Tafamidis

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物理化学性质&存储条件

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