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首页-小分子抑制剂&激动剂-Others-Other Targets-Tacrolimus
Tacrolimus

Chemical Structure : Tacrolimus

CAS No.: 104987-11-3

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Tacrolimus (FK506, Fujimycin, FR900506)

货号: PC-22184Not For Human Use, Lab Use Only.

Tacrolimus (FK506) is a macrocyclic lactone that binds to FK506 binding protein (FKBP) to form a complex, inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription, shows immunosuppressive properties.

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50 mg ￥1280 In stock
100 mg ￥1980 In stock
250 mg ￥2880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Tacrolimus (FK506) is a macrocyclic lactone that binds to FK506 binding protein (FKBP) to form a complex, inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription, shows immunosuppressive properties.

物理化学性质&存储条件

分子量 804.03
分子式 C44H69NO12
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

参考文献

1. Tocci MJ, et al. J Immunol. 1989 Jul 15;143(2):718-26.

2. Standaert RF, et al. Nature. 1990 Aug 16;346(6285):671-4.

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