TZN-23 | Ferroptosis inhibitor | Probechem Biochemicals

Chemical Structure : TZN-23

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TZN-23 (TZN23)

货号: PC-28621Not For Human Use, Lab Use Only.

TZN-23 is a potent and versatile ferroptosis inhibitor with EC50 of 13 nM across multiple cell lines, counteracts cell death induced by diverse ferroptosis inducers.

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生物&药学活性

TZN-23 is a potent and versatile ferroptosis inhibitor with EC50 of 13 nM across multiple cell lines, counteracts cell death induced by diverse ferroptosis inducers.
TZN-23 directly scavenges lipid peroxidation in vitro, thereby suppressing ferroptosis.
TZN-23 possesses excellent drug metabolism and pharmacokinetics.
TZN-23 effectively alleviated concanavalin A (ConA)-induced acute liver injury in mice by inhibiting ferroptosis.

物理化学性质&存储条件

分子量	381.78
分子式	C18H15ClF3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-chloro-1'-(4-(trifluoromethyl)phenyl)-3,4-dihydro-1H-spiro[naphthalene-2,3'-[1,2,4]triazolidin]-5'-one

参考文献

1. Hengyi Cao, et al. Eur J Med Chem. 2026 Oct 7;321(Pt 1):119396.

TZN-23 (TZN23)

生物&药学活性

物理化学性质&存储条件

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TZN-23 (TZN23)

生物&药学活性

物理化学性质&存储条件

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