TXX-1-10 | HPIP inhibitor | Probechem Biochemicals

Chemical Structure : TXX-1-10

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TXX-1-10 (CB1-8)

货号: PC-20699Not For Human Use, Lab Use Only.

TXX-1-10 (CB1-8) is a small chemical molecule that inhibits HPIP oncoprotein expression, suppresses breast cancer cell growth and metastasis in vitro and in vivo.

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1 g		Get quote

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生物&药学活性

TXX-1-10 (CB1-8) is a small chemical molecule that inhibits HPIP oncoprotein expression, suppresses breast cancer cell growth and metastasis in vitro and in vivo.
TXX-1-10 reduces HPIP expression and exerts antiproliferation effect in a HPIP-dependent manner in ZR75-1 cells.
TXX-1-10 exhibites a more effective inhibition compared with rimonabant in MDA-MB-231 and ZR-751 cells (IC50=2.2-7.0 uM).
TXX-1-10 induces G1 cell cycle arrest and apoptosis in breast cancer cells.
TXX-1-10 inhibits breast cancer cell migration and invasion in vitro, regulates genes related to cell proliferation and invasion.
TXX-1-10 (30 mg/kg) suppresses breast tumor growth and metastasis in vivo.

物理化学性质&存储条件

分子量	599.68
分子式	C23H18Cl3IN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	CC1=C(N(C2=CC=C(Cl)C=C2Cl)N=C1C(NC3=CC=C[N+](C)=C3)=O)C4=CC=C(C=C4)Cl.[I-]

参考文献

1. Pengyun Li, et al. Cell Death Discov. 2021 Jul 29;7(1):198.

TXX-1-10 (CB1-8)

生物&药学活性

物理化学性质&存储条件

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TXX-1-10 (CB1-8)

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物理化学性质&存储条件

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