TXS-8 | Rpn6 binder | Probechem Biochemicals

Chemical Structure : TXS-8

CAS No.: 2411401-41-5

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TXS-8 (TXS8)

货号: PC-47062Not For Human Use, Lab Use Only.

TXS-8 is a specific, small molecule binder of Rpn-6 with KD of 14 uM, Rpn-6 is a subunit of the 19S regulatory particle (RP) of 26s proteasome.

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生物&药学活性

TXS-8 is a specific, small molecule binder of Rpn-6 with KD of 14 uM, Rpn-6 is a subunit of the 19S regulatory particle (RP) of 26s proteasome.
TXS-8 showed binding affinity towards Rpn-6 in biochemical and cell-based assays.
TXS-8 was also preferentially cytotoxic to cancer cell lines that require significant 26S proteasome activity for survival (MM.1R and Ramos B-cells, IC50=14 uM).
TXS-8 exhibited no appreciable binding against other 19S RP subunit, including Rpn-13. a useful tool to further elucidate the role of Rpn-6.
Rpn-6 is a proteasome-associated protein that makes critical contacts with the 19S regulatory particle (19S RP)and the 20S core particle (20S CP) of the proteasome.

物理化学性质&存储条件

分子量	572.750
分子式	C34H44N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-amino-2-oxoethyl)-2-(N-(4-(tert-butyl)benzyl)-2-((2-ethoxybenzyl)amino)acetamido)-N-(2-methylbenzyl)acetamide

参考文献

1. Tian W, et al. ACS Chem Biol. 2020 Feb 21;15(2):554-561.

2. Tian W, et al. Chembiochem. 2021 Jun 2;22(11):1961-1965.

TXS-8 (TXS8)

生物&药学活性

物理化学性质&存储条件

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TXS-8 (TXS8)

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物理化学性质&存储条件

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