TXH9179 | FtsZ inhibitor | Probechem Biochemicals

Chemical Structure : TXH9179

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TXH9179 (TXH-9179 )

货号: PC-25154Not For Human Use, Lab Use Only.

TXH9179 is a next-generation benzamide-based FtsZ inhibitor, exhibits braod antibacterial activity against Clinical Isolates of MSSA, MRSA, VISA, VRSA, and LRSA with MIC of 0.25-0.5 ug/mL.

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生物&药学活性

TXH9179 is a next-generation benzamide-based FtsZ inhibitor, exhibits braod antibacterial activity against Clinical Isolates of MSSA, MRSA, VISA, VRSA, and LRSA with MIC of 0.25-0.5 ug/mL.
TXH9179 treatment caused the mislocalization of FtsZ to one or more large foci at the cell periphery.
TXH9179 is 4-fold more potent than TXA707 against a library of 55 methicillin-sensitive S. aureus (MSSA) and MRSA clinical isolates, including MRSA isolates resistant to vancomycin and linezolid.
TXH9179 induces changes in MRSA cell morphology, cell division, and FtsZ localization.
TXH9179 is not associated with any mammalian cytotoxicity.

物理化学性质&存储条件

分子量	345.32
分子式	C16H9F2N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((6-ethynylthiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide

参考文献

1. Eric Bryan, et al. ACS Chem Biol. 2023 Mar 17;18(3):629-642.

TXH9179 (TXH-9179 )

生物&药学活性

物理化学性质&存储条件

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TXH9179 (TXH-9179 )

生物&药学活性

物理化学性质&存储条件

参考文献

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