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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-TXH1033
TXH1033

Chemical Structure : TXH1033

CAS No.:

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TXH1033 (TXH-1033)

货号: PC-25155Not For Human Use, Lab Use Only.

TXH1033 is the orally active, carboxamide prodrug of TXH9179, which is a next-generation benzamide-based FtsZ inhibitor, TXH1033 is rapidly hydrolyzed to TXH9179 by serum acetylcholinesterases, exhibited in vivo efficacyin mouse model of systemic (peritonitis) MRSA infection.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TXH1033 is the orally active, carboxamide prodrug of TXH9179, which is a next-generation benzamide-based FtsZ inhibitor, TXH1033 is rapidly hydrolyzed to TXH9179 by serum acetylcholinesterases, exhibited in vivo efficacyin mouse model of systemic (peritonitis) MRSA infection.

物理化学性质&存储条件

分子量 470.49
分子式 C23H20F2N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-((6-ethynylthiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzoyl)-1-methylpiperidine-4-carboxamide

参考文献

1. Eric Bryan, et al. ACS Chem Biol. 2023 Mar 17;18(3):629-642.

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