TXD-174 | DENV inhibitor | Probechem Biochemicals

Chemical Structure : TXD-174

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TXD-174 (TXD174)

货号: PC-27768Not For Human Use, Lab Use Only.

TXD-174 is a potent, broad‐spectrum dengue virus (DENV) inhibitor with EC50 of 6.93, 3.46, 7.47 and 6.79 uM for DENV1, DENV2, DENV3 and DENV4‐infected BHK‐21 cells.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

TXD-174 is a potent, broad-spectrum dengue virus (DENV) inhibitor with EC50 of 6.93, 3.46, 7.47 and 6.79 uM for DENV1, DENV2, DENV3 and DENV4-infected BHK-21 cells.
TXD-174 (10 μM) inhibits the mRNA level of dengue virus in a concentration-dependent manner in DENV2‐infected BHK‐21 cells.
TXD‑174 markedly suppresses antibody-mediated DENV infection.
TXD-174 upregulates IL-24 in response to DENV2 infection.
TXD-174 (50 mg/kg dose) effectively mitigated virus-induced body weight loss in DENV2 infection in wild-type mice.
TXD-174 exerts potent anti-DENV2 activity by upregulating IL-24 and suppressing viral protein expression.

物理化学性质&存储条件

分子量	389.46
分子式	C25H19N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-((1H-indol-3-yl)methyl)-5-amino-3-phenyl-1H-pyrazol-1-yl)benzonitrile

参考文献

1. Han J, et al. J Med Virol. 2026 Aug;98(8):e71093.

TXD-174 (TXD174)

生物&药学活性

物理化学性质&存储条件

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TXD-174 (TXD174)

生物&药学活性

物理化学性质&存储条件

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