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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-TXA709
TXA709

Chemical Structure : TXA709

CAS No.: 1609670-80-5

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TXA709 (TXA 709)

货号: PC-49164Not For Human Use, Lab Use Only.

TXA709 is a prodrug of FtsZ-targeting benzamide compound (TXA707) with enhanced metabolic stability, demonstrates improved pharmacokinetic properties, and superior in vivo antistaphylococcal efficacy (both oral and intravenous) relative to previously identified prodrugs (TXY436 and TXY541) of PC190723.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TXA709 is a prodrug of FtsZ-targeting benzamide compound (TXA707) with enhanced metabolic stability, demonstrates improved pharmacokinetic properties, and superior in vivo antistaphylococcal efficacy (both oral and intravenous) relative to previously identified prodrugs of PC190723.

    物理化学性质&存储条件

    分子量 514.471
    分子式 C22H19F5N4O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2,6-difluoro-3-((6-(trifluoromethyl)thiazolo[5,4-b]pyridin-2-yl)methoxy)benzoyl)-1-methylpiperidine-4-carboxamide

    参考文献

    1. Kaul M, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4845-55.

    2. Lepak AJ, et al. Antimicrob Agents Chemother. 2015 Oct;59(10):6568-74.

    3. Kaul M, et al. Antimicrob Agents Chemother. 2016 Jun 20;60(7):4290-6.

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