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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-TX2-121-1
TX2-121-1

Chemical Structure : TX2-121-1

CAS No.: 1603845-42-6

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TX2-121-1

货号: PC-35752Not For Human Use, Lab Use Only.

TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor.
    TX2-121-1 induces degradation and interferences with Her2/Her3 and c-Met/Her3 interactions, prevents Her3 heterodimerization.
    TX2-121-1 induces preferential death of Her3-dependent cell lines with an EC50 in the range of 0.8-1.4 uM.

    物理化学性质&存储条件

    分子量 716.931
    分子式 C42H52N8O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-N-(2-(4-(3-(3-acrylamido-4-phenoxyphenyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)-4-(adamantan-1-yl)-2-methylbutanamide

    参考文献

    1. Xie T, et al. Nat Chem Biol. 2014 Dec;10(12):1006-12.

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