TX-1918 | HIV-1 capsid inhibitor | Probechem Biochemicals

Chemical Structure : TX-1918

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TX-1918 (TX1918)

货号: PC-20826Not For Human Use, Lab Use Only.

TX-1918 (TX1918) is a specific inhibitor of HIV-1 capsid assembly taregting the C-terminal domain of HIV-1 capsid (CA CTD) with IC50 of 3.81 uM, inhibits viral replication (EC50=15.16 μM) and inhibits CA assembly in vitro.

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生物&药学活性

TX-1918 (TX1918) is a specific inhibitor of HIV-1 capsid assembly taregting the C-terminal domain of HIV-1 capsid (CA CTD) with IC50 of 3.81 uM, inhibits viral replication (EC50=15.16 μM) and inhibits CA assembly in vitro.
TX-1918 has an antiviral EC50 of 6.57 μM and cellular cytotoxicity CC50 of 102.55 μM was obtained from a compound similarity search.
TX-1918 also is an eEF-2K inhibitor, inhibits many kinases including Src, PKA, PKC, and EGFR.

物理化学性质&存储条件

分子量	228.25
分子式	C14H12O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1/C(C(C=C1)=O)=C\C2=CC(C)=C(O)C(C)=C2

参考文献

1. Da-Wei Zhang, et al. Antiviral Res. 2019 Sep;169:104544.

2. Hori H.et al. Bioorg. Med. Chem. 10, 3257–3265. 10.1016/S0968-0896(02)00160-8.

3. Devkota A. K.et al. ChemBioChem 15, 2435–42. 10.1002/cbic.201402321.

TX-1918 (TX1918)

生物&药学活性

物理化学性质&存储条件

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TX-1918 (TX1918)

生物&药学活性

物理化学性质&存储条件

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