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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Src-TX-1123
TX-1123

Chemical Structure : TX-1123

CAS No.: 157397-06-3

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TX-1123 (TX 1123;TX1123)

货号: PC-70182Not For Human Use, Lab Use Only.

TX-1123 is a tyrphostin AG17 analog that exihibits potent Src kinase inhibitory activity with IC50 of 2.2 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TX-1123 is a tyrphostin AG17 analog that exihibits potent Src kinase inhibitory activity with IC50 of 2.2 uM.
    TX-1123 also inhibits eEF2K (IC50=3.2 uM) and PKA (IC50=9.6 uM).
    TX-1123 exhibits potent anti-tumor activity in HepG2 (EC50=3.66 uM) and HCT116 (EC50=39 uM) tumor cells.

    物理化学性质&存储条件

    分子量 312.4
    分子式 C20H24O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-4-cyclopentene-1,3-dione

    参考文献

    1. Ohkura K, et al. Anticancer Res. 2016 Jul;36(7):3645-9.

    2. Hori H, et al. Bioorg Med Chem. 2002 Oct;10(10):3257-65.

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