TVB-3166 |CAS:1533438-83-3 Probechem Biochemicals

Chemical Structure : TVB-3166

CAS No.: 1533438-83-3

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TVB-3166 (TVB3166)

货号: PC-62734Not For Human Use, Lab Use Only.

TVB-3166 is an orally-available, reversible, potent, and selective fatty acid synthase (FASN) inhibitor with biochemical IC50 of 42 nM.

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10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

TVB-3166 is an orally-available, reversible, potent, and selective fatty acid synthase (FASN) inhibitor with biochemical IC50 of 42 nM.
TVB-3166 inhibits cellular palmitate synthesis with IC50 of 60 nM, inhibits the keto-reductase enzymatic function of FASN.
TVB-3166 specifically disrupts lipid raft architecture, inhibits biological pathways such as lipid biosynthesis, PI3K-AKT-mTOR and β-catenin signal transduction, and inhibits expression of oncogenic effectors such as c-Myc in cancer cells.
TVB-3166 demonstrates anti-tumor activities in biologically diverse preclinical tumor models.

物理化学性质&存储条件

分子量	384.483
分子式	C24H24N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-{1-[5-(4,5-Dimethyl-2H-pyrazol-3-yl)-2,4-dimethyl-benzoyl]-azetidin-3-yl}-benzonitrile

参考文献

1. Ventura R, et al. EBioMedicine. 2015 Jul 2;2(8):808-24.

2. Ohol YM, et al. PLoS One. 2015 Dec 11;10(12):e0144648.

3. Heuer TS, et al. EBioMedicine. 2017 Feb;16:51-62.

TVB-3166 (TVB3166)

生物&药学活性

物理化学性质&存储条件

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TVB-3166 (TVB3166)

生物&药学活性

物理化学性质&存储条件

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