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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Fatty Acid Synthase-TVB-2640
TVB-2640

Chemical Structure : TVB-2640

CAS No.: 1399177-37-7

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TVB-2640 (Denifanstat, TVB2640)

货号: PC-72346Not For Human Use, Lab Use Only.

TVB-2640 (Denifanstat, TVB2640) is a first-in-class, potent, selective, oral fatty acid synthase (FASN) inhibitor with IC50 of 52 nM, inhibits lipogenesis with therapeutic potential against NAFLD, nonalcoholic steatohepatitis, and KRAS MUT solid tumors.

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5 mg ￥1580 In stock
10 mg ￥2580 In stock
25 mg ￥3980 In stock
50 mg ￥5880 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TVB-2640 (Denifanstat, TVB2640) is a first-in-class, potent, selective, oral fatty acid synthase (FASN) inhibitor with IC50 of 52 nM, inhibits lipogenesis with therapeutic potential against NAFLD, nonalcoholic steatohepatitis, and KRAS MUT solid tumors.

物理化学性质&存储条件

分子量 439.563
分子式 C27H29N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

>500 mM in DMSO (>220 mg/mL)
Chemical Name/SMILES

4-(1-(4-Cyclobutyl-2-methyl-5-(3-methyl-1H-1,2,4-triazol-5-yl)benzoyl)piperidin-4-yl)benzonitrile

参考文献

1. Syed-Abdul MM, et al. Hepatology. 2020 Jul;72(1):103-118.

2. Singh S, et al. Mini Rev Med Chem. 2020;20(18):1820-1837.

3. Loomba R, et al. Gastroenterology. 2021 Nov;161(5):1475-1486.

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