TUG-1375 | FFA2/GPR43 agonist | Probechem Biochemicals

Chemical Structure : TUG-1375

CAS No.: 2247372-59-2

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TUG-1375 (TUG1375;TUG 1375)

货号: PC-35695Not For Human Use, Lab Use Only.

TUG-1375 (TUG1375, TUG 1375) is a potent, selective free fatty acid receptor 2 (FFA2/GPR43) agonist with β-arrestin-2 pEC50 of 6.1 and cAMP pEC50 of 7.11.

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2 mg	￥1580	In stock
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
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生物&药学活性

TUG-1375 (TUG1375, TUG 1375) is a potent, selective free fatty acid receptor 2 (FFA2/GPR43) agonist with β-arrestin-2 pEC50 of 6.1 and cAMP pEC50 of 7.11.
TUG-1375 also shows activity on the murine FFA2 orthologue (pEC50=6.44 in the cAMP assay), displays no significant agonist or antagonist response in FFA1 (GPR40) or FFA4 (GPR120), or in nuclear receptors PPARα, PPARγ, PPARδ, LXRα or LXRβ.
TUG-1375 induces migration of human neutrophils and inhibits lipolysis in murine adipocytes.

物理化学性质&存储条件

分子量	442.542
分子式	C22H19ClN2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,4R)-2-(2-Chlorophenyl)-3-(4-(3,5-dimethylisoxazol-4-yl)benzoyl)thiazolidine-4-carboxylic acid

参考文献

1. Hansen AH, et al. J Med Chem. 2018 Sep 24. doi: 10.1021/acs.jmedchem.8b00855.

TUG-1375 (TUG1375;TUG 1375)

生物&药学活性

物理化学性质&存储条件

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TUG-1375 (TUG1375;TUG 1375)

生物&药学活性

物理化学性质&存储条件

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