TUBG1 inhibitor L12

Chemical Structure : TUBG1 inhibitor L12

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货号: PC-24204Not For Human Use, Lab Use Only.

TUBG1 inhibitor L12 is a specific inhibitor of γ-tubulin1 (TUBG1) and γ-tubule polymerizing agent, selectively inhibits TUBG1 activity in RB1-deficient tumor cells without affecting TUBG2.

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250 mg		Get quote

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生物&药学活性

TUBG1 inhibitor L12 is a specific inhibitor of γ-tubulin1 (TUBG1) and γ-tubule polymerizing agent, selectively inhibits TUBG1 activity in RB1-deficient tumor cells without affecting TUBG2.
L12 exhibits heightened toxicity in cells lacking RB1 expression (human retinoblastoma Y79, small cell lung carcinoma U1690 cells), as well as in cells with a constitutively phosphorylated RB1 (human osteosarcoma U2OS cells lacking expression of p16INK,55 leading to constitutive phosphorylation of RB1, with IC50 of 30.13 nM.
L12 selectively targets cancer cells with an impaired RB1 pathway or associated mechanisms, interferes with the activities of the TUBG–E2F1–RB1 network.
L12 increased the number of cells with γ-tubules.
L12 demonstrates less neuronal axonal toxicity compared to vincristine treatment on neuronal axons.
L12 (10 mg/kg) delays xenograft tumor growth in tumor cells with an impaired RB1 pathway in xenografted U1690 mice.

物理化学性质&存储条件

分子量	320.40
分子式	C19H20N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(6-((3-Methoxyphenyl)amino)pyrimidin-4-yl)-N,N-dimethylbenzenamine

参考文献

1. Lindström L, et al. FASEB J. 2025 Mar 15;39(5):e70431.