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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Enterovirus-TTP-8307
TTP-8307

Chemical Structure : TTP-8307

CAS No.: 950225-08-8

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TTP-8307 (TTP8307)

货号: PC-62922Not For Human Use, Lab Use Only.

TTP-8307 is a potent inhibitor of the replication of several Rhinoviruses and Enteroviruses, targets the nonstructural protein 3A, inhibits the replication of coxsackievirus B3 (CVB3 Nancy) with EC50 of 1.2 uM.

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5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TTP-8307 is a potent inhibitor of the replication of several Rhinoviruses and Enteroviruses, targets the nonstructural protein 3A, inhibits the replication of coxsackievirus B3 (CVB3 Nancy) with EC50 of 1.2 uM.
3A mutations V45A, I54F, and H57Y confer resistance to TTP-8307.

物理化学性质&存储条件

分子量 436.49
分子式 C27H21FN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(1R)-1-(4-Fluorophenyl)ethyl]-3-[2-(isoquinolin-3-yl)-1H-imidazol-4-yl]benzamide

参考文献

1. De Palma AM, et al. Antimicrob Agents Chemother. 2009 May;53(5):1850-7.

2. Arita M, et al. J Virol. 2011 Mar;85(5):2364-72.

3. Norder H, et al. Antiviral Res. 2011 Mar;89(3):204-18.

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