TTC-352 | ER mimic agonist | Probechem Biochemicals

Chemical Structure : TTC-352

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TTC-352 (TTC352)

货号: PC-72914Not For Human Use, Lab Use Only.

TTC-352 (TTC352) is a synthetic selective estrogen mimic acts as estrogen receptor (ER) partial agonist for the treatment of endocrine-resistant breast cancer.

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生物&药学活性

TTC-352 (TTC352) is a synthetic selective estrogen mimic acts as estrogen receptor (ER) partial agonist for the treatment of endocrine-resistant breast cancer.
TTC-352 yields an H-bond with Glu353, allows Asp351-to-helix 12 (H12) interaction, sealing ERα's ligand-binding domain, recruiting E2-enriched coactivators, and triggering rapid ERα-induced unfolded protein response (UPR) and apoptosis.
TTC-352 is a less potent full estrogen agonist compared to E2, allowing H12 to seal the LBD, which recruits many E2-enriched coactivators, and induces rapid ERα-mediated UPR and apoptosis.

物理化学性质&存储条件

分子量	352.379
分子式	C20H13FO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)benzo[b]thiophen-6-ol

参考文献

1. Balkees Abderrahman, et al. Mol Cancer Ther. 2021 Jan;20(1):11-25.

TTC-352 (TTC352)

生物&药学活性

物理化学性质&存储条件

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TTC-352 (TTC352)

生物&药学活性

物理化学性质&存储条件

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