TTBK1 inhibitor 31 (TTBK1-IN-1)

Chemical Structure : TTBK1 inhibitor 31

CAS No.: 2735015-60-6

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货号: PC-22792Not For Human Use, Lab Use Only.

TTBK1 inhibitor 31 (TTBK1-IN-1) is a potent, selective and CNS-penetrant Tau Tubulin Kinase 1 (TTBK1) inhibitor with IC50 of 2.7 nM, inhibits tau phosphorylation at the disease-relevant Ser 422 epitope.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TTBK1 inhibitor 31 (TTBK1-IN-1) is a potent, selective and CNS-penetrant Tau Tubulin Kinase 1 (TTBK1) inhibitor with IC50 of 2.7 nM, inhibits tau phosphorylation at the disease-relevant Ser 422 epitope.

物理化学性质&存储条件

分子量	337.38
分子式	C18H19N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Pentyn-3-ol, 1-[1-(2-amino-6-methoxy-4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-3-methyl-, (3S)-

参考文献

1. Halkina T, et al. J Med Chem. 2021 May 13;64(9):6358-6380.