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首页-小分子抑制剂&激动剂-Others-Other Targets-TTBK1-IN-2
TTBK1-IN-2

Chemical Structure : TTBK1-IN-2

CAS No.: 2765453-51-6

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TTBK1-IN-2

货号: PC-26744Not For Human Use, Lab Use Only.

TTBK1-IN-2 (Compound 29) is a potent, brain penetrant Tau-Tubulin kinase (TTBK1) inhibitor with IC50 of 0.24 uM, reduces TDP-43 phosphorylation both in vitro and in vivo.

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10 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TTBK1-IN-2 (Compound 29) is a potent, brain penetrant Tau-Tubulin kinase (TTBK1) inhibitor with IC50 of 0.24 uM, reduces TDP-43 phosphorylation both in vitro and in vivo.

物理化学性质&存储条件

分子量 336.78
分子式 C18H13ClN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(4-Chlorophenoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

参考文献

1. Nozal V, et al. J Med Chem. 2022;65(2):1585-1607.

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