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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-TTA03-107
TTA03-107

Chemical Structure : TTA03-107

CAS No.: 2397562-25-1

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TTA03-107 (TTA 03-107)

货号: PC-20197Not For Human Use, Lab Use Only.

TTA03-107 is a potent, selective HDAC1 inhibitor with Ki of 3.22 and 17.6 nM for HDAC1/2, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TTA03-107 is a potent, selective HDAC1 inhibitor with Ki of 3.22 and 17.6 nM for HDAC1/2, respectively.
    TTA03-107 (5 mg/kg/d, drinking water) exhibited antiarthritic efficacy in CIA-induced DBA/1J mice, alleviated the severity of arthritis.
    TTA03-107 reduced the severity of autoimmune arthritis without obvious adverse effects in CIA and CAIA models.
    TTA03-107 suppressed the production of inflammatory cytokines, such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-17A, in serum and joint tissue.
    TTA03-107 dampened the M1 differentiation and inflammatory cytokine production in vitro treatment of BMDMs.
    TTA03-107 also suppressed the differentiation of Th17 cells.

    物理化学性质&存储条件

    分子量 433.49
    分子式 C22H19N5O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-aminophenyl)-4-(1-((phenylsulfonyl)methyl)-1H-1,2,3-triazol-4-yl)benzamide

    参考文献

    1. Wei Zhe, et al. Biol Pharm Bull. 2022;45(9):1364-1372.

    2. Patent WO2019235501A1.

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