TTA-Q6

Chemical Structure : TTA-Q6

CAS No.: 910484-28-5

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货号: PC-21849Not For Human Use, Lab Use Only.

TTA-Q6 is a potent, selective T-type Ca2+ channel antagonist with IC50 of 14 nM and 590 nM in FLIPR depolarized assaay and FLIPR hyperpolarized assay, respectively.

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生物&药学活性

TTA-Q6 is a potent, selective T-type Ca2+ channel antagonist with IC50 of 14 nM and 590 nM in FLIPR depolarized assaay and FLIPR hyperpolarized assay, respectively.
TTA-Q6 is a potent T-type Ca(2+) channel antagonist with minimized PXR activation.
TTA-Q6 suppresses seizure frequency in a rat model of absence epilepsy and shows significant alterations of sleep architecture after oral dosing to rats.

物理化学性质&存储条件

分子量	405.81
分子式	C20H15ClF3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(6-chloro-4-cyclopropyl-2-oxo-3-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)benzonitrile

参考文献

1. Schlegel KA, et al. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5147-52.

TTA-Q6

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物理化学性质&存储条件

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TTA-Q6

生物&药学活性

物理化学性质&存储条件

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